منابع مشابه
Thrombin Generation in Zebrafish Blood.
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemostasis and thrombosis, as the hemostatic system proved to be similar to that in man. Their small size however, has been a hurdle for more widespread...
متن کامل"Normal" thrombin generation.
We have investigated the influence of alterations in plasma coagulation factor levels between 50% and 150% of their mean values for prothrombin, factor X, factor XI, factor IX, factor VII, factor VIII, factor V, protein C, protein S, antithrombin III (AT-III), and tissue factor pathway inhibitor (TFPI) as well as combinations of extremes, eg, 50% anticoagulants and 150% procoagulants or 50% pro...
متن کاملPlatelets and thrombin generation.
This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin. Studies have demonstrated that on activation, the amount of one specific lipid, phos...
متن کاملAssessment of Thrombin Generation
Thrombin plays a central role in haemostasis through both procoagulant and anticoagulant functions. Although measurement of thrombin generation in the laboratory has been possible for many years, recent advances in understanding a wider scope of physiological roles of thrombin as well as improvements in technology have resulted in methods that are less technically demanding and more reproducibl...
متن کاملInhibition of Intrinsic Thrombin Generation
BACKGROUND The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood. There are several clinically used inhibitors of intrinsic thrombin generation. Here the inhibitory concentrations 50% (IC50) of these anticoagulants are measured by the highly specific thrombi...
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ژورنال
عنوان ژورنال: Thrombosis Research
سال: 2013
ISSN: 0049-3848
DOI: 10.1016/j.thromres.2012.10.011